Thank you for your question. I do not suggest running these tablets through the machine. While they will not harm anything, they are really only meant for standalone burr grinders. The only way to run them through on the Xelsis would be to grind them up and brew them. You would have to grind many times, each time the cleaning product would also brew. This is going to leave residues from the cleaning product behind. While the grinder tablets are non toxic and safe to consume, they are going to leave calcium deposits in the brew circuit of the machine, and this will affect the flavor of the coffee brewed. The best way to clean the grinder in this machine is to scoop out all of the beans, and then take a vacuum and vacuum out the bean hopper as thoroughly as possible.